Curriculum Vitae
Publications
Simon, R, E.L. Korn, L.M. McShane, M.D. Radmacher, G. Wright and Y. Zhao. Design and Analysis of DNA Microarray Investigations, Springer Verlag (in press).
Simon, R., M.D. Radmacher, K. Dobbin and L.M. McShane. (2003). Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification. Journal of the National Cancer Institute, 95, 14-18.
McShane, L.M., M.D. Radmacher, B. Freidlin, R. Yu, M.-C. Li and R. Simon. (2002). Methods for assessing reproducibility of clustering patterns observed in analyses of microarray data. Bioinformatics, 18, 1462-1469.
Radmacher, M.D., L.M. McShane and R. Simon. (2002). A paradigm for class prediction using gene expression profiles. Journal of Computational Biology, 9, 505-512.
Simon, R., M.D. Radmacher and K. Dobbin. (2002). Design of studies using DNA microarrays. Genetic Epidemiology, 23, 21-36.
Radmacher, M.D., R. Simon, R. Desper, R. Taetle, A. Schäffer and M.A. Nelson. (2001). Graph models of oncogenesis with an application to melanoma. Journal of Theoretical Biology, 212, 535-548.
Radmacher, M.D. and T.B. Kepler. (2001). Waiting times to appearance and dominance of advantageous mutants: estimation based on the likelihood. Mathematical Biosciences, 170, 59-77.
Hedenfalk, I., D. Duggan, Y. Chen, M. Radmacher, M. Bittner, R. Simon, P. Meltzer, B. Gusterson, M. Esteller, O.-P. Kallioniemi, A. Borg and J. Trent. (2001). Gene expression profiles of hereditary breast cancer. New England Journal of Medicine, 344, 539-548.
Nelson, M. A., Radmacher, M.D., R. Simon, M. Aickin, J.-M. Yang, L. Panda J. Emerson, D. Roe, L. Adair, F. Thompson, J. Bangert, S.P.L. Lenong, R. Taetle, S. Salmon, J. Trent. (2000). Chromosome abnormalities in malignant melanoma. Clinical significance of non-random chromosome abnormalities in 206 cases. Cancer Genetics and Cytogenetics, 122, 101-109.
Bittner, M., P. Meltzer, Y. Chen, Y. Jiang, E. Seftor, M. Hendrix, M. Radmacher, R. Simon, Z. Yakhini, A. Ben-Dor, E. Dougherty, E. Wang, F. Marincola, C. Gooden, J. Lueders, A. Glatfelter, P. Pollock, E. Gillanders, D. Leja, K. Dietrich, C. Beaudry, M. Berens, D. Alberts, V. Sondak, N. Hayward and J. Trent. (2000). Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature, 406, 536-540.
Radmacher, M.D. and R. Simon. (2000). Estimation of tamoxifen's efficacy for preventing the formation and growth of breast tumors. Journal of the National Cancer Institute, 92, 48-53.
Radmacher, M.D., G. Kelsoe and T.B. Kepler. (1998). Predicted and inferred waiting times for key mutations in the germinal center reaction: Evidence for stochasticity in selection. Immunology and Cell Biology, 76, 373-381.Presentations
Avoiding pitfalls in the analysis of DNA microarray data. Ohio Speaker's Circuit Talk, Mathematics Department, Oberlin College, February 2003.
Statistical issues in the design and analysis of tissue microarray studies. NCI Cooperative Prostate Cancer Tissue Resource Coordinating Committee Meeting, Medical College of Wisconsin, April 2002.
McShane, L., M.D. Radmacher and R. Simon. Statistical analysis of microarray data. Short course presented at the Eastern North American Region Spring Meeting of the International Biometric Society, Arlington, VA, March 2002.
A paradigm for class prediction using gene expression profiles. Statistics in Functional Genomics, Mount Holyoke College, June 2001.
Issues relating to the statistical design and data analysis of gene-expression and tissue microarrays. MGED3, Stanford University, March 2001.
Class prediction based on gene expression data: issues in the design and analysis of experiments. Workshop on Expression Arrays, Genetic Networks and Diseases. Institute for Pure and Applied Mathematics, UCLA, November 2000.
Assessing the reproducibility of tumor and gene cluster structures derived from gene expression profiles. Eighth International Workshop on Chromosomes in Solid Tumors, Tucson, Arizona, January 2000.
Production and selection of key mutations in the germinal center reaction: estimates of times to first arrival, establishment and dominance. Society for Mathematical Biology Annual Meeting, NCSU, August 1997.
Production and selection of key mutations in the germinal center reaction: estimates of times to first arrival, establishment and dominance. International Conference on Mathematical Models in Medical and Health Sciences, Vanderbilt University, May 1997.